What is the lipemia index?
The HIL Index is widely used by laboratories using chemistry analyzers to identify samples showing possible interference due to hemolysis, icterus, or lipemia at a concentration increased enough to cause an increase or decrease in the analyte concentration by 10% (1).
What is serum indices?
Liquichek Serum Indices is intended for use as part of laboratory interference testing to monitor an instrument’s response in detecting hemolyzed, icteric or lipemic (HIL) samples to help improve detection of pre-analytical errors affecting clinical chemistry testing.
What does Lipaemic mean?
Lipaemia is defined as an abnormally high concentration of lipids in the blood, usually in the form of very low density lipoproteins (VLDLs) or chylomicrons. Characteristically the blood plasma may appear white or milky in colour due to the presence of fat.
What makes a sample lipemic?
The most common preanalytical cause of lipemic samples is inadequate time of blood sampling after the meal or parenteral administration of synthetic lipid emulsions. Unlike for other interferences, lipemia can be removed and measurement can be done in a clear sample.
Does lipemia affect triglycerides?
Lipemia can be detected visually if the concentration of triglycerides in patient sample is over 3.4 mmol/L (32). In the full blood samples, visual detection is very hard and can be observed at much higher concentration of triglycerides (over 11.3 mmol/L) (32).
How do you prevent lipemia?
One way to avoid grossly lipemic samples is to ask that patients fast for 12 hours before sample collection. If this is impractical, a mechanical-based means of clot detection should be available when samples are grossly lipemic.
How are serum indices measured?
The Serum Indices Gen. 2 assay is based on calculations of absorbance measurements of diluted samples at different dichromatic wavelength pairs to provide a semi-quantitative representation of levels of lipemia, hemolysis and icterus present in serum and plasma samples.
Why is it important to measure and report serum indices report?
Serum indices (SI) is a tool which guides laboratory professionals about interferences, increases the quality of the sample, and minimizes aberrant test results. It has been reported that hemolysis accounts for 40%–70% of unsuitable specimens sent to the clinical laboratory [5, 6].
What causes lipemic blood?
The most common cause of lipemia is nonfasting, with recent ingestion of lipid-containing meal. More severe lipemia results from a disease condition causing hypertriglyceridemia (eg, diabetes, genetic hyperlipidemia) or recent intravenous infusion of a lipid emulsion.
How do you prevent lipemic blood?
Please avoid food with high fat content before blood donation. If a blood donor consumes food with high fat content such as oily foods which are fried or deep fried before blood donation it can lead to a transient rise in the triglycerides or cholesterol levels resulting in lipemic blood.
How do you reduce lipemia?
Conclusions and Future Directions Moderate-high intensity aerobic and resistance exercise produce consistent reductions in postprandial lipemia when performed 30 minutes to 20 hours prior to mixed or high-fat meals.
Does lipemia affect AST?
Comparison of the results of native serum, serum blank, and diluted serum with ultracentrifuged serum. In moderate lipemia (700–1000 mg/dl), as shown in Table 3, only ALT, ALP, amylase, AST, bilirubin, and uric acid are not influenced by lipemia.
